Press Release (ePRNews.com) - TORONTO - Oct 31, 2018 - Up to 90 percent of the drugs in the pharmaceutical pipeline are classified as poorly soluble, according to the Biopharmaceutical Classification System. Amorphous solid dispersions have emerged as one of the preferred methods to increase aqueous solubility of drugs.
Selection of polymer and optimal active pharmaceutical ingredient (API) load in an amorphous solid dispersion is critical for the performance and stability of the dispersion. Formulation screening can be a time and material consuming exercise with a heavy analytical workload. The use of computational methods and miniaturization tools provides a reduction of material requirements and development time while enabling a formulation platform to increase API exposure and its development success.
The formulation of an amorphous solid dispersion into a tablet is the subsequent step that will define the ultimate presentation of the amorphous solid dispersion. The tablet formulation must ensure that the performance of the solid dispersion is not affected by the densification, and in some cases, the final formulation step may be driven to further improve performance.
This live webinar upcoming on Monday, Nov. 19, 2018 at 11 a.m. EST (8 a.m. PST / 4 p.m. GMT), will focus on several aspects of the formulation screening of amorphous solid dispersions, for both the drug product intermediate and the final drug product. Different in-silico and miniaturization techniques will be presented to reduce experimental work while maximizing the generation of information. This approach decreases the overall development time and initial API requirements while optimizing the amorphous solid dispersion physical stability and drug product performance and target a right-first-time development program.
Join featured speakers from Hovione Joao Henriques, MSc, Team Leader and Paulo Lino, Ph.D., Scientist, for an informative and interactive presentation.
For more information about this complimentary event visit: Amorphous Solid Dispersions: Increasing Solubility From API to Tablet.
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Nima Rajan Source :
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