Danna B. Zimmer

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A New Model for Heart Valve Disease Drug Discovery

A New Model for Heart Valve Disease Drug Discovery

An article published in Experimental Biology and Medicine (Volume 244, Issue 3, February, 2019) (https://journals.sagepub.com/doi/pdf/10.1177/1535370219829006) describes a new model for heart valve physiology. The study, led by Dr. Carla Lacerda, from the Department of Chemical Engineering at Texas Tech University…

Heart Remodeling During Pregnancy and the Early Postpartum Period

Heart Remodeling During Pregnancy and the Early Postpartum Period

An article published in Experimental Biology and Medicine (Volume 243, Issue 15/16, November, 2018) (https://journals.sagepub.com/doi/pdf/10.1177/1535370218818457) provides new insights regarding the molecular events underlying cardiac remodeling during pregnancy and the early post-partum period. The study, led by Dr. Holly LaVoie, Department…

GABA-Receptor Modulation in the Treatment of Neurological Diseases

GABA-Receptor Modulation in the Treatment of Neurological Diseases

An article published in Experimental Biology and Medicine (Volume 243, Issue 13, September 2018)(https://journals.sagepub.com/doi/full/10.1177/1535370218800980) identifies new mechanisms that regulate the activity of the most common type of receptor in the mammalian brain, GABA receptors. The study, led by Dr. Sergiy Sylantyev in…

Vascular Stress Contributes to Age-Associated Vision Loss

An article published in Experimental Biology and Medicine (Volume 243, Issue 12, August, 2018 (http://journals.sagepub.com/doi/full/10.1177/1535370218794915) reports that vascular stress exacerbates age-associated vision loss. The study, led by Dr. Rajashekhar Gangaraju, in the Department of Ophthalmology and the Department of Anatomy…

Dronedarone Promotes Cardiac Repair After a Heart Attack

An article published in Experimental Biology and Medicine (Volume 243, Issue 11, July, 2018) (http://journals.sagepub.com/doi/pdf/10.1177/1535370218788517) reports that the antiarrhythmic drug, dronedarone, promotes cardiac repair after a heart attack. The study, led by Dr. Uwe Lendeckel, Professor for Medical Biochemistry and…

A New Environmental Risk Factor for Inflammatory Bowel Disease

An article published in Experimental Biology and Medicine (Volume 243, Issue 10, June, 2018)  (http://journals.sagepub.com/doi/full/10.1177/1535370218782139) identifies a new environmental risk factor for inflammatory bowel disease (IBD). The study, led by Dr. Clint Allred in the Department of Nutrition and Food…

Alterations in Copper Homeostasis in Ischemic Heart Disease

An article published in Experimental Biology and Medicine (Volume 243, Issue 9, May 2018) answers a long-standing clinical question regarding elevated blood copper levels in patients with myocardial ischemia (http://journals.sagepub.com/doi/full/10.1177/1535370218773055). The study, led by Dr. Y. James Kang in the…

Supporting Cells in the Heart Contribute to Cardiac Disease

Supporting Cells in the Heart Contribute to Cardiac Disease

An article published in Experimental Biology and Medicine (Volume 243, Issue 7, April, 2018) reports that supporting cells in the heart, known as fibroblasts, are selectively activated by factors present in heart disease. The study, led by Dr. Megan McCain,…

Hemozoin Contributes to Lung Failure in Severe Malaria

An article published in Experimental Biology and Medicine (Volume 243, Issue 5, March, 2018) identifies a new pathway that contributes to lung failure in patients with malaria. The study, led by Dr. Sumate Ampawong, in the Department of Tropical Pathology…

A Personalized Diagnostic Assay for the Treatment of Knee Injuries

An article published in Experimental Biology and Medicine (Volume 242, Issue 18, December 2017) describes a new approach for profiling patients with joint injuries. The study, led by Dr. Ursula Anderer, Professor for Cell Biology and Head of the Department Cell…

Advances in Microphysiological Systems

​​The latest issues of Experimental Biology and Medicine (Volume 242, Issues 16 and 17, October and November, 2017) highlight recent advances in microphysiological systems (MPS). The issues were guest edited by Dr. John P. Wikswo, founding Director of the Vanderbilt…

A Novel Biomarker for Multiple Sclerosis

An article published in Experimental Biology and Medicine (Volume 242, Issue 15, September 2017) identifies Opioid Growth Factor (OGF) as a novel biomarker for the onset and progression of multiple sclerosis (MS). The study, led by Dr. Patricia McLaughlin, Professor…

A Plant Based Delivery System for Anti-Cancer Drugs

An article published in Experimental Biology and Medicine (Volume 242, Issue 14, August 2017) reports that a plant virus-based system can be used to deliver anti-cancer drugs. The study, led by Dr. Nicole Steinmetz in the Department of Biomedical Engineering…

Lipoprotein Abnormalities Contribute to Sickle Cell Disease Pathology

​An article published in Experimental Biology and Medicine (Volume 242, Issue 12, June, 2017) links imbalances in lipoprotein metabolism with vaso-occlusive events in patients with sickle cell disease (SCD). The study, led by Dr. Eric Soupene in Dr. Frans Kuypers’…

Pyruvate Reduces Brain Injury After Cardiac Arrest

An article published in Experimental Biology and Medicine (Volume 242, Issue 10, May, 2017) identifies a new treatment that may protect the brain from irreversible damage caused by cardiac arrest. The study, led by Dr. Robert Mallet, Professor of Cardiovascular…

Delta-Opioid Agonists Can Attenuate Cardiac Injury

An article published in Experimental Biology and Medicine (Volume 242, Issue 9, May, 2017) describes a new treatment for minimizing injury to the heart during cardiac procedures. The study, led by Dr. Paul Iaizzo from the Department of Surgery and…

Targeting Cancer Cells With an Implantable Drug Delivery System

​An article published in Experimental Biology and Medicine (Volume 242, Issue 7, March, 2017) describes a new drug delivery system for the treatment of cancer. The study, led by Dr. Horst A. von Recum from the Department of Biomedical Engineering…

Suppressing Vasculogenic Mimicry in Breast Cancer

​An article published in Experimental Biology and Medicine (Volume 242, Issue 6, March, 2017) identifies a new signaling pathway involved in breast cancer cell growth. The study, led by Dr. Chan-Wha Kim, from the Department of Biotechnology at Korea University…

Targeting Chemokine Signaling to Overcome Radiation Resistance in Colorectal Cancer

An article published in Experimental Biology and Medicine (Volume 242, Issue 4, February, 2017) identifies a new pathway that renders colon cancers resistant to radiation therapy. The study, led by Dr. Zhuoxin Cheng, from the First Affiliated Hospitals of Harbin…

miRNA Modulators of Transcription Factor Targets: Potential Treatments for Hemoglobinopathies

​An article published in Experimental Biology and Medicine (Volume 242, Issue 3, February, 2017) identifies microRNAs (miRNAs) as key factors in some hemoglobinopathies, genetic disorders characterized by alterations in the level or structure of the globin proteins that are responsible…

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