Julie Langelier

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Discovery of How HIV Hedges Its Bets Opens the Door to New Therapies

A stem cell is one with infinite possibilities. So, for decades, scientists have puzzled over how the cell chooses to keep being a stem cell and continue dividing or specialize into a specific cell type, like a heart or brain…

Deep Learning: A Superhuman Way to Look at Cells

It’s harder than you might think to look at a microscope image of an untreated cell and identify its features. To make cell characteristics visible to the human eye, scientists normally have to use chemicals that can kill the very…

Scientists Learn How to Avoid a Roadblock When Reprogramming Cells

Over a decade ago, Shinya Yamanaka and Kazutoshi Takahashi made a discovery that would revolutionize biomedical research and trigger the field of regenerative medicine. They learned how to reprogram human adult cells into cells that behave like embryonic stem cells.…

Scientists Fix Genetic Risk Factor for Alzheimer's Disease in Human Brain Cells

Scientists Fix Genetic Risk Factor for Alzheimer's Disease in Human Brain Cells

Using human brain cells, scientists at the Gladstone Institutes discovered the cause of — and a potential solution for — the primary genetic risk factor for Alzheimer’s disease, a gene called apoE4. Having one copy of the apoE4 gene more…

Cell Therapy Could Improve Brain Function for Alzheimer's Disease

Cell Therapy Could Improve Brain Function for Alzheimer's Disease

Like a great orchestra, your brain relies on the perfect coordination of many elements to function properly. And if one of those elements is out of sync, it affects the entire ensemble. In Alzheimer’s disease, for instance, damage to specific…

Unlocking a Cell's Potential to Regenerate the Heart

Unlocking a Cell's Potential to Regenerate the Heart

Some organisms have a remarkable capacity for regenerating tissue. If a fish or salamander suffers heart damage, for instance, their cells are able to divide and successfully repair the injured organ. Imagine if you could do the same. In the…

A New Hub for Cutting-Edge Technologies in Mission Bay

A New Hub for Cutting-Edge Technologies in Mission Bay

Science is becoming increasingly driven by advanced technologies that are fundamentally changing the way research is conducted. But too often, the experts developing the technologies and the scientists interpreting the data these technologies produce are separated in different university departments,…

Uniquely Human DNA Sequences Control Brain Development

Uniquely Human DNA Sequences Control Brain Development

The most striking genetic differences between humans and chimpanzees are, perhaps unsurprisingly, involved in the development of our brains. Stretches of DNA that make us uniquely human are partly responsible for controlling neuron growth, according to new research from the…

Researchers Create First Stem Cells Using CRISPR Genome Activation

Researchers Create First Stem Cells Using CRISPR Genome Activation

In a scientific first, researchers at the Gladstone Institutes turned skin cells from mice into stem cells by activating a specific gene in the cells using CRISPR technology. The innovative approach offers a potentially simpler technique to produce the valuable…

Gladstone Institutes Announces Research Collaboration With Lilly

Gladstone Institutes Announces Research Collaboration With Lilly

The Gladstone Institutes announced today a new research collaboration with Eli Lilly and Company focused on neurodegenerative diseases. This multi-year, milestone-driven project will be based on a combination of innovative technologies developed at Gladstone by Steve Finkbeiner, M.D., Ph.D. His laboratory…

An Anti-Aging Protein Could Be Targeted to Rejuvenate Immune Cells

An Anti-Aging Protein Could Be Targeted to Rejuvenate Immune Cells

Anti-aging proteins have long been shown to protect against age-related diseases, such as cancer, neurodegeneration, and cardiovascular disease. A study by researchers at the Gladstone Institutes now reveals that one such protein could also be targeted to rejuvenate cells in…

Blood-Clotting Protein Prevents Repair in the Brain

Blood-Clotting Protein Prevents Repair in the Brain

Picture a bare wire, without its regular plastic coating. It’s exposed to the elements and risks being degraded. And, without insulation, it may not conduct electricity as well as a coated wire. Now, imagine this wire is inside your brain.…

Growing Human Brain Cells in the Lab

Growing Human Brain Cells in the Lab

Li Gan, PhD, wants to find treatments to help patients with Alzheimer’s disease. Like most researchers, she’s hit a few major roadblocks. When researchers like Gan find potential new drugs, they must be tested on human cells to confirm they…

Deepak Srivastava Appointed President of Gladstone Institutes

Deepak Srivastava Appointed President of Gladstone Institutes

Deepak Srivastava, MD, has been appointed president of Gladstone Institutes, thus succeeding outgoing President R. Sanders (Sandy) Williams, MD. Srivastava’s term will begin on Jan. 1, 2018. He is currently a senior investigator and director of the Gladstone Institute of…

Patients With Unsolved Diseases Could Be Treated Sooner Than Expected

Patients With Unsolved Diseases Could Be Treated Sooner Than Expected

In the United States, developing a new pharmaceutical drug can cost between $160 million and $2.5 billion. This high price tag is one of the reasons many deadly conditions remain without an effective treatment. When a drug is first designed,…

On a Quest to Improve Treatments for Inflammatory Bowel Disease

On a Quest to Improve Treatments for Inflammatory Bowel Disease

​Scientist Shomyseh Sanjabi, PhD, joined the Gladstone Institutes seven years ago, and she brought with her a special type of mice that develop inflammatory bowel disease (IBD). Coincidentally, microbiome expert Katherine Pollard, PhD, was looking for a model to study…

New Study Reveals Cells can be Reprogrammed in Our Immune System

New Study Reveals Cells can be Reprogrammed in Our Immune System

When the immune system is imbalanced, either due to overly-active cells or cells that suppress its function, it causes a wide range of diseases, from psoriasis to cancer. By manipulating the function of certain immune cells, called T cells, researchers…

Additional Funding to Develop a Drug for Alzheimer’s Disease

Additional Funding to Develop a Drug for Alzheimer’s Disease

E-Scape Bio announced an extension of its Series A funding to a total of $63 million. Created as a spin-off from research conducted at the Gladstone Institutes, E-Scape Bio is a biopharmaceutical company with a mission to develop new therapies to…

Proteins Linked to HIV Transmission Could Actually Be Beneficial for Reproduction

Proteins Linked to HIV Transmission Could Actually Be Beneficial for Reproduction

Protein fragments found in semen, and previously only known for their ability to enhance HIV infection, also appear to play an important role in reproductive biology. A team of researchers from the Gladstone Institutes, the University of California, San Francisco…

Deepak Srivastava to Lead the International Society for Stem Cell Research Beginning in 2019

Deepak Srivastava to Lead the International Society for Stem Cell Research Beginning in 2019

Deepak Srivastava, MD, was elected vice president of the International Society for Stem Cell Research (ISSCR), the voice of the global stem cell research community. Srivastava, who pioneered the use of stem cells for heart disease, is director of the…

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