Gladstone Institutes

Julie Langelier

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Uniquely Human DNA Sequences Control Brain Development

Uniquely Human DNA Sequences Control Brain Development

The most striking genetic differences between humans and chimpanzees are, perhaps unsurprisingly, involved in the development of our brains. Stretches of DNA that make us uniquely human are partly responsible for controlling neuron growth, according to new research from the…

Researchers Create First Stem Cells Using CRISPR Genome Activation

Researchers Create First Stem Cells Using CRISPR Genome Activation

In a scientific first, researchers at the Gladstone Institutes turned skin cells from mice into stem cells by activating a specific gene in the cells using CRISPR technology. The innovative approach offers a potentially simpler technique to produce the valuable…

Gladstone Institutes Announces Research Collaboration With Lilly

Gladstone Institutes Announces Research Collaboration With Lilly

The Gladstone Institutes announced today a new research collaboration with Eli Lilly and Company focused on neurodegenerative diseases. This multi-year, milestone-driven project will be based on a combination of innovative technologies developed at Gladstone by Steve Finkbeiner, M.D., Ph.D. His laboratory…

An Anti-Aging Protein Could Be Targeted to Rejuvenate Immune Cells

An Anti-Aging Protein Could Be Targeted to Rejuvenate Immune Cells

Anti-aging proteins have long been shown to protect against age-related diseases, such as cancer, neurodegeneration, and cardiovascular disease. A study by researchers at the Gladstone Institutes now reveals that one such protein could also be targeted to rejuvenate cells in…

Blood-Clotting Protein Prevents Repair in the Brain

Blood-Clotting Protein Prevents Repair in the Brain

Picture a bare wire, without its regular plastic coating. It’s exposed to the elements and risks being degraded. And, without insulation, it may not conduct electricity as well as a coated wire. Now, imagine this wire is inside your brain.…

Growing Human Brain Cells in the Lab

Growing Human Brain Cells in the Lab

Li Gan, PhD, wants to find treatments to help patients with Alzheimer’s disease. Like most researchers, she’s hit a few major roadblocks. When researchers like Gan find potential new drugs, they must be tested on human cells to confirm they…

Deepak Srivastava Appointed President of Gladstone Institutes

Deepak Srivastava Appointed President of Gladstone Institutes

Deepak Srivastava, MD, has been appointed president of Gladstone Institutes, thus succeeding outgoing President R. Sanders (Sandy) Williams, MD. Srivastava’s term will begin on Jan. 1, 2018. He is currently a senior investigator and director of the Gladstone Institute of…

Patients With Unsolved Diseases Could Be Treated Sooner Than Expected

Patients With Unsolved Diseases Could Be Treated Sooner Than Expected

In the United States, developing a new pharmaceutical drug can cost between $160 million and $2.5 billion. This high price tag is one of the reasons many deadly conditions remain without an effective treatment. When a drug is first designed,…

On a Quest to Improve Treatments for Inflammatory Bowel Disease

On a Quest to Improve Treatments for Inflammatory Bowel Disease

​Scientist Shomyseh Sanjabi, PhD, joined the Gladstone Institutes seven years ago, and she brought with her a special type of mice that develop inflammatory bowel disease (IBD). Coincidentally, microbiome expert Katherine Pollard, PhD, was looking for a model to study…

New Study Reveals Cells can be Reprogrammed in Our Immune System

New Study Reveals Cells can be Reprogrammed in Our Immune System

When the immune system is imbalanced, either due to overly-active cells or cells that suppress its function, it causes a wide range of diseases, from psoriasis to cancer. By manipulating the function of certain immune cells, called T cells, researchers…

Additional Funding to Develop a Drug for Alzheimer’s Disease

Additional Funding to Develop a Drug for Alzheimer’s Disease

E-Scape Bio announced an extension of its Series A funding to a total of $63 million. Created as a spin-off from research conducted at the Gladstone Institutes, E-Scape Bio is a biopharmaceutical company with a mission to develop new therapies to…

Proteins Linked to HIV Transmission Could Actually Be Beneficial for Reproduction

Proteins Linked to HIV Transmission Could Actually Be Beneficial for Reproduction

Protein fragments found in semen, and previously only known for their ability to enhance HIV infection, also appear to play an important role in reproductive biology. A team of researchers from the Gladstone Institutes, the University of California, San Francisco…

Deepak Srivastava to Lead the International Society for Stem Cell Research Beginning in 2019

Deepak Srivastava to Lead the International Society for Stem Cell Research Beginning in 2019

Deepak Srivastava, MD, was elected vice president of the International Society for Stem Cell Research (ISSCR), the voice of the global stem cell research community. Srivastava, who pioneered the use of stem cells for heart disease, is director of the…

Study Could Help Explain Link Between Seizures and Psychiatric Disorders

Study Could Help Explain Link Between Seizures and Psychiatric Disorders

In a new study published in Cell Reports, scientists at the Gladstone Institutes identified different types of neurons in a brain region called the reticular thalamus. A better understanding of these cells could eventually help explain how both seizures and…

New Study Helps Solve a Great Mystery in the Organization of Our DNA

New Study Helps Solve a Great Mystery in the Organization of Our DNA

​​​After decades of research aiming to understand how DNA is organized in human cells, scientists at the Gladstone Institutes have shed new light on this mysterious field by discovering how a key protein helps control gene organization. Humans have nearly…

Cancer-Cardiac Connection Illuminates Promising New Drug for Heart Failure

Cancer-Cardiac Connection Illuminates Promising New Drug for Heart Failure

A team of researchers at the Gladstone Institutes uncovered a new strategy to treat heart failure, a leading contributor to mortality and healthcare costs in the United States. Despite widespread use of currently-approved drugs, approximately 40% of patients with heart…

Study Reveals a New Method to Address a Major Barrier to Eradicating HIV

Study Reveals a New Method to Address a Major Barrier to Eradicating HIV

Scientists at the Gladstone Institutes discovered that an enzyme called SMYD2 could be a new therapeutic target for flushing out the HIV that hides in infected individuals. Overcoming this latent virus remains the most significant obstacle to a cure. While…

Discovery Offers New Hope to Repair Spinal Cord Injuries

Discovery Offers New Hope to Repair Spinal Cord Injuries

Scientists at the Gladstone Institutes created a special type of neuron from human stem cells that could potentially repair spinal cord injuries. These cells, called V2a interneurons, transmit signals in the spinal cord to help control movement. When the researchers…

Inflammatory Pathways Link to Obsessive Behaviors in a Common Form of Dementia

Inflammatory Pathways Link to Obsessive Behaviors  in a Common Form of Dementia

Scientists from the Gladstone Institutes identified that mutations in a protein commonly linked to frontotemporal dementia (FTD) result in obsessive-like behaviors. They linked these behaviors to immune pathways, implicating that targeting key components of the immune system could be a…

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