Press Release (ePRNews.com) - Toronto, ON - Jun 12, 2018 - The aim of a crystallization process is to produce the optimal solid form with all desired properties such as particle size, particle shape, bulk density, purity, yield, residual solvent content, etc. In order to reach this goal, many steps need to precede the crystallization development.
In a salt and/or co-crystal screening and characterization, the optimal salt or co-crystal has to be identified. This is followed by a polymorph and solvate screening of the corresponding substance where all relevant forms are identified, characterized and their thermodynamic relationships are determined. Very often either the thermodynamically stable form at room temperature or a hydrate is selected. Knowledge of critical water activities for hydrate formation and kinetics of hydration and dehydration is therefore essential.
After selecting the optimal form, a small scale (10mL to 250mL) crystallization process – using state-of-the-art equipment such as Lasentec probes – is developed in order to obtain the selected form with the desired particle size distribution and purity, while optimizing yield, speed, etc. Very often a seeded crystallization process is required in order to achieve optimal control. This process is then further scaled up in a kilo-lab, followed by production on a kg-scale in a GMP facility.
Join the Vice President and Head of Department Solid-State Development at Solvias, Dr. Rolf Hilfiker, on Monday, June 25, 2018 at 11am EDT (4pm BST/UK), to learn about crystallization development and how quick communication and efficient know-how transfer between the scientists of the various disciplines assures a very efficient and fast process.
For more information about this complimentary webinar visit: Crystallization Development – From Solid Form Screening to a GMP Crystallization Process
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