Media Newsroom of

Oncotelic Inc

United States
Website: http://oncotelic.com
Oncotelic Inc

Oncotelic is developing TGF- β2 antisense as immunotherapy against pancreatic, melanoma, and glioblastoma. IL-8 spike was predictive of TGF β2 immunotherapy probably due to its potentiation of the cytokine storm during immunotherapy. IL-8 spike during 1st cycle of therapy is associated with improved overall survival in pancreatic cancer patients treated with Trabedersen/OT-101 – above and beyond those seen with current treatments.

Oncotelic is part of Autotelic consortium of companies focusing on late stage drug development.  Autotelic works through partners to transform how medications are being delivered. The Autotelic Inc. platform is aTherapeutic Drug Monitoring (TDM) device which allows PK guided dosing, reducing the toxicity from overmedication and increasing the efficacy from under-medication. Current dosing schemes result in either too much drug exposure or too little drug exposure because of individual pharmacokinetic variations. The Autotelic pipeline includes TDM devices for management of oncology, hypertension and pain.

Oncotelic and Autotelic Inc. Present to Present Data on OT-101 Program at 2017 American Association for Cancer Research Annual Meeting

Overexpression of transforming growth factor-beta 2 (TGF-β2) is associated with poor prognosis of tumors and plays a key role in malignant progression of various tumors by inducing proliferation, metastasis, angiogenesis, and immunosuppression. Oncotelic is developing a TGF-β2 antisense agent (OT-101)…

Oncotelic and Autotelic Inc. Present Clinical Data at 2017 GI Cancer Symposium to Support IL-8 Positive Association with Survival

Overexpression of transforming growth factor-beta 2 (TGF-β2) is associated with poor prognosis of tumors and plays a key role in malignant progression of various tumors by inducing proliferation, metastasis, angiogenesis, and immunosuppression. Oncotelic is developing a TGF-β2 antisense agent (OT-101)…

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